Common name niclosamide (BSI, E-ISO, (m) F-ISO, BAN, Germany (for veterinary use))
IUPAC name 2’, 5-dichloro-4’-nitrosalicylanilide
Chemical Abstracts name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide CAS RN [50-65-7]
PHYSICAL CHEMISTRY
Mol. wt. 327.1
Form Almost colourless crystals.
M.p. 230 ºC
V.p. <1 mPa (20 ºC)
KOW logP = 1 (pH 9.6)
Solubility In water 1.6 (pH 6.4), 110 (pH 9.1) (both in mg/l, 20 ºC). Soluble in common organic solvents such as ethanol and diethyl ether.
Stability Hydrolysed in aqueous solution, DT50 (20 ºC) c. 7 d (pH 6.9), 18.8 d (pH 13.3). Stable to heat. Decomposes under u.v. irradiation. Hydrolysed by concentrated acid or alkali.
APPLICATIONS
Mode of action Molluscicide with respiratory and stomach action.
Uses Control of golden apple snail in rice. Control of schistosomiasis and fascioliasis in man by killing fresh-water snails which act as intermediate hosts. Also used for veterinary control of tapeworm infestations.
Compatibility Incompatible with acidic materials.
Selected tradenames: Bayluscide
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